CADD Solis Flowstop cassette supplies for patients prescribed intravenous epoprostenol

Friday 22nd July 2022

There have been small improvements in this situation over the last couple of months, which suggest supplies may now last for four weeks at a time. Homecare companies have now been able to resume monthly delivery of stock to patients. However, we still consider this to still be a fragile situation. It is our desire to see stock levels of at least 12 weeks in the UK and we continue to work with all parties to secure a long-term resolution.

Dr Iain Armstrong, Chair, PHA UK

This is a further update on a supply issue affecting CADD Solis Flowstop cassettes, which are used by around 100 UK pulmonary hypertension patients prescribed intravenous epoprostenol.

The cassettes must be imported from the USA and since May 2022, the manufacturers have encountered critical logistical problems that have made it difficult to transport them over here.  

Currently, there is adequate stock within specialist centres for patients in hospital. The homecare delivery companies (who deliver cassettes) also have some stock available. Over the last couple of months, they have continued to take delivery of small batches that, at present, allow for patients to receive four-week supplies.

You should always hold an additional ‘buffer’ supply of two weeks at home.

Previously, we were concerned that the situation may reach a point where those who use these cassettes may need to be admitted to hospital to receive their medication by other methods. We are now confident that the situation has improved enough that we see this as a small possibility only if things deteriorate significantly.

Please be reassured that supplies of the drug itself are not affected, only the cassettes, so you will never be without your medication.

What is being done to try and solve the supply problem?

Clinical PH services and the Pulmonary Hypertension Association (PHA UK) are working hard with the manufacturer, homecare delivery companies and government agencies at the highest level, to try to get these supply issues resolved as quickly and safely as possible.

The Department of Health’s Emergency Preparedness, Resilience and Response Team is now involved and as always, the UK’s specialist centres are working together so that a collaborative solution can be found.

Who should I contact if I have any questions or concerns about this?

If you have any queries about your current stock levels, please contact your homecare delivery company urgently. Please do not contact your specialist centre as their stock is needed for patients in hospital.

The PHA UK will continue to provide updates via this web page and on our social media channels.