Who gets PH? Pulmonary hypertension (PH) affects many different types of people. In most people with PH, it is associated with another medical condition. Conditions that increase your risk of developing PH include: portal hypertension connective tissue disease, e.g. systemic sclerosis HIV infection congenital heart disease sickle cell anaemia. A small number of people with PH develop it without having another medical condition. For most of these people there is no known reason behind their PH. This is called idiopathic PH. In very rare cases, PH can be inherited.